Copyright 2023 CBS Interactive Inc. All rights reserved. The Novavax vaccine will be manufactured in two different facilities. CDC endorses ACIPs updated COVID-19 vaccine recommendations. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Adjuvants and vaccines. This article provides a summary of those interim recommendations. / CBS News. Recombinant protein-based nanoparticle vaccine, Global vaccine authorization / approval map, Diversity matters: Inclusivity in clinical trials, From pandemic to endemic: Why COVID-19 may be here to stay, Standing on the shoulders of giants: How a Novavax vaccine is developed, Recombinant nanoparticle vaccine technology, Global vaccine authorization/approval map, Global authorization site of Novavax COVID-19 Vaccine (recombinant, adjuvanted), Ask medical questions, report adverse events, and product quality complaints, Pay Transparency Nondiscrimination Provision. My hope is a lot of patients that have had hesitancy about the mRNA vaccines, because theyre using novel and new technology, will be less reluctant to get vaccinated for COVID-19 using a traditional vaccine like Novavax, he told MNT. U.S. Department of Health and Human Services. Contact: Media Relations "Novavax gives us another way to protect ourselves from COVID-19. Now, youll enjoy a streamlined experience created specifically for healthcare providers. With COVID-19 cases on the rise again across parts of the country, vaccination is critical to help protect against the complications of severe COVID-19 disease., ### Similar to the other COVID-19 vaccines, the Novavax COVID-19 vaccine can cause mild side effects that typically go away after a few days. Before sharing sensitive information, make sure you're on a federal government site. . The body recognizes the spike protein as something foreign it needs to defend itself from, causing an immune response. Complete and submit reports to VAERS online. Centers for Disease Control and Prevention. The Novavax COVID-19 vaccine is the first COVID-19 protein subunit vaccine recommended for use in the United States. The Novavax vaccine is available on a walk-in basis Monday - Saturday from 8 a.m. - 5 p.m. at the Robert B. Pro rata thresholds for jurisdictions have been set based on the unvaccinated adult population in each jurisdiction. Adults ages 18 years and older should receive a two-dose primary series separated by three to eight weeks. With the mRNA vaccines, the inflammation, in most cases, gets better on its own without treatment. It provides another option for people who cant or dont want to receive the other COVID-19 vaccines. "The American public can trust that this vaccine, like all vaccines that are used in the United States, has undergone the FDA's rigorous and comprehensive scientific and regulatory review," said Marks. Nuvaxovid is packaged as a ready-to-use liquid formulation in a vial containing ten doses. We have details on all the COVID-19 vaccines and boosters available to eligible adults and children at WeCanDoItSA.com. Novavax reported a net loss of $352 million, or $4.75 per share, for the second quarter of 2021, far higher than its net loss of $18 million for the same period in 2020. Anyone with a body temperature over 38.5C should postpone vaccination until they no longer have a fever. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention. (2021). Centers for Disease Control and Prevention. Novavax COVID-19 Vaccine, Adjuvanted is available under emergency use authorization (EUA) to prevent COVID-19 in individuals 12 years of age and older. But a spokesperson for at least one of the program's participants, CVS, said their drug stores have "no immediate plans to offer the Novavax vaccine at our retail locations.". Its not an option if youre fully vaccinated and considering your options for a booster shot. We don't know yet, Dr. Wilson says. The booster dose is given 3 months or more after the primary course. So, you may be wondering why the FDA recently authorized a fourth vaccine option for adults the Novavax COVID-19 vaccine. Some of the previous COVID-19 vaccines namely Pfizer and Moderna utilize mRNA technology. That could mean the first shots of Novavax's vaccine will not arrive in doctors offices and pharmacies until August a timeline previously floated by health authorities. With the mRNA vaccines, particularly in older people, the duration of immune response seems to fall off after four to six months, Dr. Wilson says, adding that there is now data to show this is the case with Omicron. That means its an option for people who havent been vaccinated yet. Novavax's vaccine had solid efficacy estimates in a clinical trial published in February in The New England Journal of Medicine. States will not be able to begin ordering from the Biden administration's supply of Novavax's vaccine until the week of July 25, the document "tentatively" estimates. The Novavax vaccine is the fourth vaccine authorized by the Food and Drug Administration (FDA) in the U.S. for the prevention of COVID-19and another tool in an expanding armamentarium. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our. Novavax is committed to accelerating the development of new and promising vaccines by building on years of study and experience. The U.S. Department of Health and Human Services (HHS), in collaboration with the Department of Defense (DOD), today announced that it has secured 3.2 million doses of Novavax's COVID-19 vaccine. The Pfizer COVID-19 bivalent vaccine is available to kids between the ages of five and 11 as a first shot or as a booster. You can review and change the way we collect information below. The vaccine is actively under review in other markets and has ongoing trials to further explore its efficacy and safety as a booster. Teenagers ages 12 through 17 who had the Novavax primary series must get a Pfizer-BioNTech bivalent booster. Novavax is a protein subunit vaccine that uses the same, long-used, technology seen in other widely used vaccines such as HPV, hepatitis B, and flu. The forward-looking statements in this press release speak only as of the date of this document, and we undertake no obligation to update or revise any of the statements. Novavax COVID-19 vaccine: What are the side effects? Always seek the individual advice of your health care provider with any questions you have regarding a medical condition. The protein is derived from the coronavirus spike protein and is formulated with Novavaxs patented saponin-based Matrix-M adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies. The information that is available comes from before the Delta and Omicron variants emerged. For further assistance with reporting to VAERS, call 1-800-822-7967. Like the other vaccine manufacturers, Novavax is currently working on Omicron-based vaccines. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Novavax is based in Maryland, and the vaccine was developed in the U.S. in 2020 with support from the federal government program Operation Warp Speed, but it's progress was slowed by . We have more than a decade of experience contending with some of the world's most devastating diseases, including COVID-19, seasonal influenza, RSV, Ebola, MERS, and SARS. But individuals may choose to delay vaccination for 3 months following the infection. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. The Novavax COVID-19 vaccine, has received authorization from multiple regulatory authorities globally, including the U.S. FDA, the European Commission, and the World Health Organization. (2022). The Novavax coronavirus vaccine (brand names: Nuvaxovid and Covovax) is already being used to prevent the coronavirus in 40 other countries, including Canada. Thats what it is, Dr. Wilson says. They help us to know which pages are the most and least popular and see how visitors move around the site. Coronavirus Disease 2019 (COVID-19), Recalls, Market Withdrawals and Safety Alerts, COVID-19-Related Guidance Documents for Industry, FDA Staff, and Other Stakeholders, Fact Sheet for Healthcare Providers Administering Vaccine, HOJA INFORMATIVA PARA RECEPTORES Y PROVEEDORES DE CUIDADO, FACT SHEET PARA SA MGA TATANGGAP AT MGA TAGAPAG-ALAGA, T THNG TIN CHO NGI NHN V NHNG NGI CHM SC. Subunit vaccines, such as the Novavax COVID-19 vaccine candidate, use a small part of a pathogen to train our immune system to fight off future. Its given as a two-dose primary series, 3 weeks apart. Call 210-358-2335 or email us for more information about University Health news. One is that this is an additional vaccine choice that may be acceptable to some of the more than 30% of Americans who are not fully vaccinated, he explains. Nuvaxovid should be given with caution in individuals receiving anticoagulant therapy or those with thrombocytopenia or any coagulation disorder (such as haemophilia) because bleeding or bruising may occur following an intramuscular administration in these individuals. , for a discussion of these and other risks and uncertainties. The Novavax COVID-19 vaccine is an adjuvanted protein-based vaccine. In August, authorization for the vaccine was expanded to include adolescents ages 12 to 17, based on data from Novavaxs ongoing pediatric trial. Novavax creates transformational vaccines that help address some of the worlds most pressing infectious diseases. Note: Information in this article was accurate at the time of original publication. Click "Continue" only if you are a US medical professional. COVID-19 vaccines for children: What are the side effects. So, its combined with an adjuvant a substance that helps boost your immune response against it. A limited quantity of doses will be held in reserve and distributed based on need.. The spike protein in this vaccine is produced in insect cells; the Matrix M-adjuvant contains saponin extracts from the bark of the Soapbark tree that is native to Chile. (2021). Finally, in November 2021, countries around the world, starting with Indonesia and the Philippines, later followed by the United Kingdom, began granting authorizations for the vaccine. The FDA's independent Vaccines and Related Biological Products Advisory Committee voted in favor of. (2022). This timeline is the latest delay for Novavax's vaccine reaching unvaccinated adults, now more than six weeks after the company's shots won the near-unanimous backing of the FDA's outside vaccine advisers on June 7. A two-dose primary series to individuals 12 years of age and older. The Novavax COVID-19 vaccine, sold under the brand names Nuvaxovid and Covovax, [1] among others, is a subunit COVID-19 vaccine developed by Novavax and the Coalition for Epidemic Preparedness Innovations (CEPI). The shot is given six months after the primary vaccine to adults only if they have not received any booster shot previously, and they cannot receive a Pfizer-BioNTech or Moderna mRNA bivalent booster for a medical or any other reason. This webpage was updated on 28 September 2022 to reflected updated interim recommendations. Adolescents with moderate to severe immunocompromising conditions belong to the highest priority-use group. U.S. Department of Health and Human Services. The Novavax vaccine is available on a walk-in basis Monday . These cookies may also be used for advertising purposes by these third parties. The company submitted their EUA based off of 2 phase 3 clinical trials they conducted with 1 using nearly 30,000 participants that were randomized between December 27, 2020 and . Thank you for taking the time to confirm your preferences. "We are pleased to collaborate with SK bioscience to offer our protein-based vaccine, Nuvaxovid, for use as a booster in adults regardless of previous vaccine history," said Stanley C. Erck, President and Chief Executive Officer, Novavax. (It injects a version of the spike protein that has been formulated in a laboratory as a nanoparticulate that does not have genetic material inside and cannot cause disease.). U.S. Food and Drug Administration. This Snapshot feature offers an overview of Nuvaxovid, Novavax's COVID-19 vaccine, and what we currently know about its potential side effects. WHO lists 10th COVID-19 vaccine for emergency use : Nuvaxovid, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Independent Oversight and Advisory Committee, Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the Novavax NVX-CoV2373 vaccine against COVID-19, The Novavax vaccine against COVID-19: What you need to know. In fact, vaccines like the hepatitis B, HPV, and shingles vaccines all fall into this category. Complete and submit reports to VAERS online. Even so, the vaccines have been proven to be a valuable tool in preventing serious illness and death from COVID-19. The incidence of Grade 3 or higher events remained relatively low. Trade Name in the U.S.The trade name Nuvaxovid has not yet been approved by the U.S. Food and Drug Administration (FDA). adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies. Around 16% of those unvaccinated adults told a CDC survey that they "probably" or "definitely" will get vaccinated if a protein-based vaccine like Novavax was available. Participants received either two doses of Novavax or two doses of a saline placebo. Before this . The efficacy of Novavax(NVX-CoV2373) in adolescents 12 to 17 years of age was evaluated in an interim analysis of the paediatric expansion portion of the ongoing phase 3 study in United States. While the mRNA bivalent boosters from Pfizer and Moderna target both the original strain of the coronavirus and Omicron BA.4 and BA.5 subvariants, the Novavax booster only targets the original SARS-CoV-2 virus. But, unlike the other vaccines, Novavax directly injects a version of the spike protein, along with another ingredient that also stimulates the immune system, into the body, leading to the production of antibodies and T-cells. You can unsubscribe at any time. It is impossible to compare vaccine head-to-head due to the different approaches taken in designing the respective studies, but overall, all of the vaccines that have achieved WHO Emergency Use Listing are highly effective in preventing severe disease We anticipate the first doses of Novavax could be available in some locations as early as this week, they added. Novavax is a little different than the other COVID-19 vaccines available in the US. They help us to know which pages are the most and least popular and see how visitors move around the site. This type of vaccine contains an antigen (protein) thats unique to a germ. I would also like to sign up for a free GoodRx account, Written by Tracy Norfleet, MD, MBA, FACP, ABOM. In addition to its COVID-19 vaccine, is also currently evaluating its COVID-19-Influenza Combination (, influenza investigational vaccine candidate, and an Omicron strain-based vaccine (NVX-CoV2515) as well as a bivalent format Omicron-based / original strain-based vaccine. Injection-site reactions (pain, redness, swelling). Commission authorises fifth safe and effective vaccine. According to the CDC, doses should be available in the coming weeks. Novavax is not responsible for the privacy policy of any third-party websites. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. In view of these findings, WHO recommends the use of Novavax (NVX-CoV2373) vaccine according to the WHO Prioritization Roadmap, even if currently recognized Variants of Concern (VOC) are present in the country. Protein subunit vaccines package harmless proteins of the COVID-19 virus alongside another ingredient called an adjuvant that helps the immune system respond to the virus in the future. Novavax COVID-19 Vaccine, Adjuvanted indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Perhaps you havent felt comfortable with the Pfizer or Moderna vaccines the preferred COVID-19 vaccine options. CDC twenty four seven. 1. You will be subject to the destination website's privacy policy when you follow the link. If so, talk to your healthcare provider about the Novavax COVID-19 vaccine. Your immune system may not respond as strongly to the spike protein on its own. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Individuals with a history of anaphylaxis to any component of the vaccine should not take it. In the Novavax-sponsored trials, following the booster, local and systemic reactions had a median duration of approximately two days. During clinical trials, it was found to be over 90% effective in preventing serious illness from COVID-19. And its given as an injection into the muscle of your upper arm. The Technical Advisory Group for Emergency Use Listing listed Nuvaxovid (NVX-CoV2373) vaccine against COVID-19 and Covovax (NVX-CoV2373) vaccine against COVID-19 for emergency use on 20 December 2021 and 17 December 2021 respectively. What it means for you If you've received your primary vaccine at. We also want multiple production lines that potentially can be updated to address new variants and meet the challenges as they come.. We take your privacy seriously. FDA requires vaccination providers to report vaccine administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of COVID-19 vaccine under an EUA. Protein-based vaccines have been around for awhile. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. Vaccination should be postponed in individuals suffering from an acute severe febrile illness or acute infection. Novavax COVID-19 vaccine, adjuvanted. and NVX-CoV2373 in addressing vaccine access, increasing vaccination rates, controlling the pandemic, and protecting populations, the efficacy, safety, intended utilization, and expected administration of NVX-CoV2373 are forward-looking statements. The Novavax COVID-19 vaccine uses more conventional vaccine technology compared to the Pfizer, Moderna, and Johnson & Johnson vaccines. A COVID-19 vaccine that many have been keeping a close eye on will be arriving in British Columbia in the next week to 10 days. In mid-July 2022, the U.S. government released a statement saying it secured 3.2 million doses of the Novavax COVID-19 vaccine. (2022). Events of anaphylaxis have been reported with administration of COVID-19 vaccines. Research into other effective coronavirus vaccines continues, including at UC Davis Health. Even though Pfizer-BioNTech and Moderna mRNA vaccines are safe and highly effective, weve heard a lot of people say the reason they've chosen not to get an mRNA vaccine is because the mRNA technology is relatively new and it hasn't been tried on a wide scale before., There are practical reasons as well. Then, in October, the FDA authorized a booster for adults only, although it may not prevent infection by the most recent variants. The company's proprietary recombinant technology platform harnesses the power and speed of genetic engineering to efficiently produce highly immunogenic nanoparticles designed to address urgent global health needs. Government advice on public health and social measures should continue to be followed by both vaccinated and unvaccinated individuals. The vaccine is authorized for. Novavax, Inc (Nasdaq:NVAX) is a biotechnology company that creates transformational vaccines that address some of the world's most pressing infectious diseases. Information provided in Yale Medicine articles is for general informational purposes only. These vaccine candidates incorporate Novavax' proprietary saponin-based Matrix-M adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies. CDC recommends Novavaxs COVID-19 vaccine for adults. WHO recommends the use of the Novavax (NVX-CoV2373) vaccine in pregnant persons when the benefits of vaccination to the pregnant persons outweigh the potential risks. Though COVID vaccines may utilize different delivery mechanisms, the end result is the same: cells in the body recognize that a spike protein (the spikes you see sticking out of the coronavirus in pictures) doesnt belong, and the immune system reacts by activating immune cells and producing antibodies to attack the real virus if you get exposed. It requires receiving two injections every 6 months that can help prevent COVID-19. There may be some genetic factors at play, too, but that's still all up in the air., As to whether people should be concerned about the risk, he says, The risk of myocarditis is higher from COVID than it is from any of the COVID vaccines.. "This is an important step in ensuring broad access to diversified vaccine options.". Pfizer, Moderna and Johnson & Johnson were quickest off the mark in getting COVID vaccines into American arms, but Novavax is hoping to add another pandemic vaccine to the U.S. Updated on: July 21, 2022 / 8:13 AM Novavax has demonstrated its ability to quickly produce viable vaccine candidates for emerging infectious diseases such as COVID-19. GoodRx is not sponsored by or affiliated with any of the third-party brands identified. "We are working feverishly to get a lower format of presentations that we can submit to the regulators and get approval in due course," Novavax's Filip Dubovsky said at a meeting of the CDC's advisers on Tuesday. Nuvaxovid (NVX-CoV2373) is a protein-based vaccine engineered from the genetic sequence of the first strain of SARS-CoV-2, the virus that causes COVID-19. Novavax, a small American company buoyed by lavish support from the U.S. government, announced on Monday the results of a clinical trial of its Covid-19 vaccine in the United States . By providing your email address, you agree to receive emails containing coupons, refill reminders and promotional messages from GoodRx. But individuals may choose to delay vaccination for 3 months following the infection. Spike proteins are also found in SARS-CoV-2 virus cells. The U.S. could soon have a new COVID vaccine on the market but this one will be different from the others. They will later be supplemented with data from additional manufacturing sites throughout Novavax' global supply chain. Jun 7, 2022. WHO looking forward to oral, nasal COVID vaccines. On July 13, 2022, the FDA announced it had granted emergency use authorization for Novavax a new vaccine for COVID-19. Some people are also recommended to have a second booster dose (fourth dose) 3 months after the first booster dose. As part of the Novavax Phase 2 trials, a single booster dose of Nuvaxovid was administered to adult participants approximately six months after their primary two-dose vaccination series of Nuvaxovid. Novavax' COVID-19 vaccine is authorized for use as an adult booster in more than 35 countries, and a number of other countries have policy recommendations allowing use of the vaccine as a booster dose. (2022). After receiving a vaccine dose, your immune system sees the foreign protein and knows it doesnt belong. Please seek medical advice before starting, changing or terminating any medical treatment. All data and statistics are based on publicly available data at the time of publication. As there is not currently sufficient evidence to date to evaluate the impact of the vaccine on transmission, public health and social measures must continue, including use of face masks, physical distancing, handwashing, appropriate ventilation, and other measures as appropriate in particular settings, depending on the COVID-19 epidemiology and potential risks of emerging variants. Approximately 21,000 vaccine recipients had at least two months of safety follow-up after their second dose, according an FDA statement. Novavax COVID-19 Vaccine, Adjuvanted is available under emergency use authorization (EUA) to prevent COVID-19 in individuals 12 years of age and older. Existing authorizations leverage Novavax' manufacturing partnership with Serum Institute of India, the world's largest vaccine manufacturer by volume. Thats where I think the real benefit is going to come from, in reducing the burden on our hospitals and saving more lives over time.. For further assistance with reporting to VAERS, call 1-800-822-7967. Anxiety-related reactions, including vasovagal reactions (syncope), hyperventilation, or stressrelated reactions may occur in association with vaccination as a psychogenic response to the needle injection. At least part of the delay in supplying Novavax's doses appears to be the result of quality testing still ongoing to clear the company's shots, which is only now wrapping up. A first booster dose is recommended 4-6 months after the completion of the primary series. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Green pharmacy at 903 W. Martin Street. It provides an alternative option for people who cant or dont want to receive the other COVID-19 vaccines. Because of this, some people have been hesitant to get vaccinated. Each Novavax shot contains 5 mcg of spike protein. Allergic reactions: After your shot, you may be asked to wait around for about 15 to 30 minutes to be monitored for a reaction. Cookies used to make website functionality more relevant to you. (2021). Study in humans confirms link between Parkinson's and gut bacteria imbalance, Multiple Sclerosis (MS): Stem cell treatment may prevent worsening of symptoms, Lifestyle factors may help prevent many inflammatory bowel disease cases, Why a history of obesity may increase macular degeneration risk. Its ideal to have more than one or two companies being the sole providers of vaccines, Dr. Wilson says. Novavax. Deep meditation: Might it change the gut microbiome to boost health? Thank you for taking the time to confirm your preferences. June 14, 2021. An official website of the United States government, : The Novavax COVID-19 Vaccine (NVX-CoV2373) is an investigational SARS-CoV-2 vaccine for the prevention of COVID-19. It is important that precautions are in place to avoid injury from fainting. Testing later showed that those changes did not appear to impact the purity or quality of the shots. The company's proprietary recombinant technology platform harnesses the power and speed of genetic engineering to efficiently produce highly, designed to address urgent global health needs. These conditions are typically treatable, so its important to seek medical attention right away if symptoms develop. For the purposes of this article, the vaccine will be referred to as Novavax (NVX-CoV2373). GAITHERSBURG, Md., Jan. 18, 2023 /PRNewswire/ -- Novavax, Inc. (Nasdaq: NVAX), abiotechnology company dedicated to developing and commercializing next-generation vaccines for serious infectious diseases, today announced that partner SK bioscience has received expanded manufacturing and marketing approval from the Korean Ministry of Food and Drug Safety (KMFDS) for Nuvaxovid (NVX-CoV2373) for use as a booster for active immunization to prevent COVID-19 in adults aged 18 and older. For more information on Nuvaxovid, including the Summary of Product Characteristics with Package Leaflet, Prescribing Information and Important Safety Information, adverse event reporting instructions, or to request additional information, please visit the following websites: About Nuvaxovid (NVX-CoV2373)Nuvaxovid (NVX-CoV2373) is a protein-based vaccine engineered from the genetic sequence of the first strain of SARS-CoV-2, the virus that causes COVID-19. On Monday, the U.S. Department of Health and Human Services announced that the Biden administration had secured 3.2 million doses of Novavax's COVID-19 vaccine. Novavax receives positive European Medicines Agency recommendation for conditional marketing authorization of its COVID-19 vaccine. It's unclear how those initial batches of Novavax's vaccine will be divided up by the Biden administration between states and other federal vaccination channels like drug stores or health centers. The vaccine is stored at 2- 8 Celsius, enabling the use of existing vaccine supply and cold chain channels. adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies. In Korea, SK bioscience signed a licensing agreement with Novavax and is manufacturing drug substance and drug product of Nuvaxovid for domestic use. WHO does not recommend CDC COVID data tracker: Variant proportions. It is also available as a booster to adults 18 years . Of the two Phase 3 trials, both found that the efficacy of the vaccine against mild, moderate, and severe disease is 90%. In this Special Feature, we outline what we know about the side effects of COVID-19 vaccines that some health authorities have approved for use in.
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